Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review
Some mixtures of medications can lead to serious and even fatal consequences. To view an interaction report containing 4 (or more) medications, please sign in or create an account. To view a report comparing 3 (or more) medications, please sign in or create an account.
The risk of dependence is increased when benzodiazepines are prescribed alongside opioid drugs like fentanyl. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Older adults may be more sensitive to the side effects of this drug, especially confusion, drowsiness, constipation, or trouble urinating. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
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Structurally, venlafaxine is similar to tramadol, and in mice, venlafaxine demonstrates opioid-mediated analgesia that is reversed by naloxone. Duloxetine has a Food and Drug Administration indication for both diabetic peripheral neuropathic (DPN) pain and for MDD. Thus, it is an excellent choice for pain patients with psychiatric co-morbidity who have failed to respond to a TCA.
As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current. Zanaflex is used to treat conditions such as multiple sclerosis or spinal injury. It is used in adjuvant therapy and in physiotherapy with other drugs. Muscle spasms are sudden and involuntary muscle tightness or contractions, and are most often caused by muscle fatigue or injury.
Higher doses of cyclobenzaprine or tizanidine would be appropriate to promote sedation in cases of more severe discomfort or perceived muscular spasm. Although there appears to be insufficient data on metaxalone and methocarbamol, these may be useful in patients who cannot tolerate the sedative properties of cyclobenzaprine or tizanidine. Of note, methocarbamol costs substantially less than metaxalone. There is insufficient evidence to suggest that one skeletal muscle relaxant is better than the others. In some cases, these drugs may be combined with other medication, but this is subject to careful consideration by a physician due to potential drug interactions.
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If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Ask your healthcare professional how you should dispose of any medicine you do not use. The amount of medicine that you take depends flexeril.live on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For example, slow-release morphine sulfate has been shown to improve not only pain, but also dystonic movement in some patients with primary and tardive dystonia (Berg et al., 2001). Besides clonazepam, GHB, used in the treatment of alcohol abuse, has been found to be beneficial in the treatment of myoclonus–dystonia syndrome (Priori et al., 2000). It is not known whether acamprosate, another drug that is used in the treatment of alcohol abuse, is useful in the treatment of myoclonus–dystonia.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
- While people tend to think of sedatives as “sleeping pills,” the types used as muscle relaxers prevent nerve signals or pain impulses from reaching the brain.
- Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.
- After several weeks if there is no response, the dosage may be increased under medical supervision.
- The first line of treatment for muscle spasms and muscle pain is over-the-counter medications like Tylenol (acetaminophen) and nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen).
- Nonetheless, due to its unique pharmacology, Norflex may be an ideal choice for patients who did not respond well to other muscle relaxants or have specific needs such as avoiding common side effects like sedation.
A side effect is an unwanted response to a medication when it is taken in normal doses. It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. No information is available on the relationship of age to the effects of orphenadrine in geriatric patients. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require caution in patients receiving orphenadrine . Appropriate studies have not been performed on the relationship of age to the effects of orphenadrine in the pediatric population.